Next-generation biosensors for drug discovery and life sciences
The Creoptix® WAVEsystem | made in Switzerland
High-throughput, automated, clog-free, label-free kinetics. Get superior affinity and kinetic data, even for the most challenging samples. Save time and costs.
Biomolecular Interaction Analysis - Creoptix® WAVEsystem
Study real-time biological interactions involving fragment, small molecules, peptides, membrane proteins, biologics and other molecules even in crude reaction mixtures and biofluids like undiluted serum and plasma.
Screening of crude reaction mixtures
In this TechNote we show how the WAVEsystem provides a reliable environment to support optimisation of hits in fragment-based drug discovery. With high sensitivity and robust microfluidics, the WAVEsystem offers kinetic data in excellent agreement with Biacore T200 measurements. This is illustrated through a retrospectively measured Vernalis campaign to identify selective, potent inhibitors of Pyruvate Dehydrogenase Kinase 2 (PDHK2) and Heat Shock Protein 90 (HSP90).
Pushing the boundaries in pharmaceutical hit discovery with the novel waveRAPID® kinetic assay
In this TechNote, conducted by an HTS drug discovery group of our customer Idorsia Pharmaceuticals Ltd, we demonstrate the power of waveRAPID in streamlining the kinetic characterization of large numbers of drug hit compounds, with results comparable to traditional SPR and high reproducibility.
The Creoptix’ WAVE technology aids us best in discovering better drug molecules