Applications

Experience real kinetics with the WAVEsystem

Study real-time biological interactions involving fragment, small molecules, peptides, membrane proteins, biologics and other molecules even in crude reaction mixtures and biofluids like undiluted serum and plasma.

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  Small Molecules

  Separate binders from non-binders.

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  Membrane Proteins

  Kinetics while retaining conformation and activity.

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  Serology

  Binding kinetics in conditions closer to real life.

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  Biologics

  Confirm and validate ELISA data.

COVID-19 Research

It’s through innovation and technologies like the Creoptix^® WAVEsystem that advance discovery and understanding. Find out more here.

Kinetics: it's all in the curvature

The Creoptix^® WAVEsystem allows you to confidently detect and quantify biological interactions in real-time, providing you with both binding affinity and kinetics. An interaction between two species (a protein and a small molecule, for example) is displayed as a graph, referred to as a sensorgram, showing binding response vs. time. Though the signal level in a sensorgram correlates to the species involved and the strength of their interaction, it’s in the curvature of its association and dissociation phases where the valuable information resides. So is, for example, the desired biological effect of a drug linked to its residence time (dissociation phase) rather than to its affinity only.

• Measure interactions, not interference

  WAVEcore®

  Engineered around a proprietary Grating-Coupled Interferometry (GCI) technology, the Creoptix^® WAVE system builds on waveguide interferometry to achieve superior resolution in signal and time. With low limits of detection, the WAVEsystem generates accurate kinetic rates, affinity constants, and concentrations of label-free biomolecular interactions, even at low analyte abundance, with no loss of definition.

  

• Faster, More Sensitive Kinetic Analysis

  WAVEsystem brochure

  The Creoptix™ WAVEsystem brochure explains how Grating-Coupled Interferometry (GCI), robust microfluidics, and automated software are combined in a single platform to provide a breakthrough level of kinetic analysis

  

• Faster, More Sensitive Kinetic Analysis

  Molecular Interaction Analysis Poster

  The following poster explains how Grating-Coupled Interferometry (GCI), robust microfluidics, and automated software combined can provide a breakthrough level of kinetic analysis

  

• Faster, More Sensitive Kinetic Analysis

  Biomolecular Interaction Analysis Poster

  The Creoptix™ WAVEsystem brochure explains how Grating-Coupled Interferometry (GCI), robust microfluidics, and automated software are combined in a single platform to provide a breakthrough level of kinetic analysis

  

• A sensor chip for every need

  WAVEchip®

  WAVEchip^®- Innovative design and patented microfluidic cartridge to support crude samples, pathogenic samples, harsh solvents, and large particles up to 1000 nm normally only achieved with plate-based assays for kinetic analysis not possible before

  

• Choose the Right WAVEchip® for your Application

  WAVEchip® brochure

  Download the WAVEchip® quickguide brochure to discover the right WAVEchip® for your application. Ordering information included.

  

• Choose the Right WAVEchip® for your Application

  Interactive chip finder

  You are four steps away from finding the right WAVEchip® for your application.

  

• Smooth operations

  WAVEcare

  Our WAVEcare programs offer carefree or basic support for high-quality kinetic data and unparalleled performance. Ensure the continuous, high performance operation of your WAVEsystem by choosing the program that fits your needs.

  

• Identify the service that best meets your needs

  WAVEcare brochure

  Including an easy-to-view comparison of the different options available, it also explains the importance of scheduling a regular preventative maintenance visit from one of our qualified service engineers.

  

• Fast, intuitive, automated

  WAVEcontrol

  Move seamlessly from sample to data in a simple stepwise process, generating outputs at the touch of a button. Benefit from waveRAPID, a novel method implemented on the existing WAVEdelta instruments allowing you to obtain kinetics of an interaction by injections from a single well.

  

• Streamline your workflow with the WAVEcontrol software

  WAVEcontrol brochure

  The WAVEcontrol brochure reveals how workflow-based software provides complete control over biomolecular interaction analysis.