Applications

Kinetic data is the foundation for assessing molecular and protein interactions, so shouldn’t that data be as accurate and relevant as possible?

Experience real kinetics with the WAVEsystem

Study real-time biological interactions involving fragment, small molecules, peptides, membrane proteins, biologics and other molecules even in crude reaction mixtures and biofluids like undiluted serum and plasma.

COVID-19 Research

It’s through innovation and technologies like the Creoptix® WAVEsystem that advance discovery and understanding. Find out more here.

Kinetics: it's all in the curvature

The Creoptix® WAVEsystem allows you to confidently detect and quantify biological interactions in real-time, providing you with both binding affinity and kinetics. An interaction between two species (a protein and a small molecule, for example) is displayed as a graph, referred to as a sensorgram, showing binding response vs. time. Though the signal level in a sensorgram correlates to the species involved and the strength of their interaction, it’s in the curvature of its association and dissociation phases where the valuable information resides. So is, for example, the desired biological effect of a drug linked to its residence time (dissociation phase) rather than to its affinity only.

Sensorgram webfinal