Kinetic data is the foundation for assessing molecular and protein interactions, so shouldn’t that data be as accurate and relevant as possible?
Kinetics: it's all in the curvature
The Creoptix® WAVEsystem allows you to confidently detect and quantify biological interactions in real-time, providing you with both binding affinity and kinetics. An interaction between two species (a protein and a small molecule, for example) is displayed as a graph, referred to as a sensorgram, showing binding response vs. time. Though the signal level in a sensorgram correlates to the species involved and the strength of their interaction, it’s in the curvature of its association and dissociation phases where the valuable information resides. So is, for example, the desired biological effect of a drug linked to its residence time (dissociation phase) rather than to its affinity only.