While retaining conformation and activity
Real is Unpurified
With the sensitivity and versatility to measure analyte-membrane protein interactions in a wide variety of sample matrices, the Creoptix WAVEsystem enables more detailed investigation of membrane protein pharmacology, providing, for example, real-time drug binding affinities and label-free kinetics.
Stay close to native state in cell membrane and study molecular interactions with large binding partners
More than buffer
Membrane proteins are notoriously difficult to study due to the requirement for a membrane-mimicking environment and their instability once extracted from a cellular membrane. Here we show the capability of the WAVE to measure the interaction of a peptide ligand agonist (NTA11) with a thermostabilized variant of the neurotensin receptor 1 (NTSR1) at highest resolution.
The WAVEsystem can be used for the kinetic analysis of G-protein binding onto detergent-solubilized, unpurified GPCRs. By shortening a typical 10-step purification process, this method requires significantly less material (30mL of cell culture) and less time (less than 1 hour), thereby offering an alternative for screening purposes at an early stage of the drug discovery process involving membrane proteins.
No clogging, regardless of size
Take advantage of the Creoptix WAVEsystem’s valveless microfluidics to analyze and characterize larger molecules.
Push the limits and generate high-quality binding kinetics with our sensitive GCI technology and resolve data at very low responses
The Creoptix’ WAVE technology aids us best in discovering better drug molecules