Kinetics on Membrane Proteins
While retaining conformation and activity
Stay close to native state in cell membrane and study molecular interactions with large binding partners
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More than buffer
Membrane proteins are notoriously difficult to study due to the requirement for a membrane-mimicking environment and their instability once extracted from a cellular membrane. Here we show the capability of the WAVE to measure the interaction of a peptide ligand agonist (NTA11) with a thermostabilized variant of the neurotensin receptor 1 (NTSR1) at highest resolution.
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Save time
The WAVEsystem can be used for the kinetic analysis of G-protein binding onto detergent-solubilized, unpurified GPCRs. By shortening a typical 10-step purification process, this method requires significantly less material (30mL of cell culture) and less time (less than 1 hour), thereby offering an alternative for screening purposes at an early stage of the drug discovery process involving membrane proteins.
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No clogging, regardless of size
Take advantage of the Creoptix WAVEsystem’s valveless microfluidics to analyze and characterize larger molecules.
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High sensitivity
Push the limits and generate high-quality binding kinetics with our sensitive GCI technology and resolve data at very low responses
The Creoptix’ WAVE technology aids us best in discovering better drug molecules
