A sensor chip for every need

No-clog microfluidic design explained

The innovative design of our patented microfluidic cartridge supports crude samples, pathogenic samples, harsh solvents, and large particles up to 1000 nm, enabling reliable kinetic analysis. WAVEchips can be exchanged within minutes for fresh microfluidics.

Our WAVEchips are compatible with:

  • 100% Serum & plasma & cell supernatant
  • Non-traditional solvents, including high percentages of acetonitrile and DMSO
  • Viscous detergents and additives to solubilize membrane proteins
  • Cell membrane preps, partially solubilized, unpurified material
  • Virus-like particles (VLPs), liposomes, or nanodiscs used as solubilization structures
  • Large binding partners: nanoparticles and crude membrane preps

Innovative, No-Clog Microfluidic Cartridge

The innovative design of our patented microfluidic cartridge supports crude samples, pathogenic samples, harsh solvents, and large particles up to 1000 nm normally only achieved with plate-based assays for kinetic analysis not possible before.

Measure the toughest samples

Maintaining samples in native configuration and physiological conditions reduces the risk of protein inactivation or denaturation, ensuring the raw data generated is a faithful depiction of kinetic activity. However, large particles above 100nm in diameter tend to clog other systems.

By combining the microfluidics and biosensor in a single disposable cartridge, Creoptix WAVE system offers crude-sample robustness normally only achieved with plate-based assays. Compatible sample types include 100% serum or plasma, cell lysates, crude membranes preparations, large drug targets, virus-like particles (VLPs), liposomes, and aggregates (fibrils) without clogging-risk.

The chemical-friendly cartridge also makes it amenable to work with high concentrations of DMSO, acetonitrile, and other organic solvents typical of fragment libraries, and viscous detergents allowing exploration of solubilization and purification conditions for membrane proteins. And because the cartridges are self-contained and disposable, they eliminate cross-contamination protecting your samples and ensuring more reliable data.

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No-Clog for Crude Samples

No-clog microfluidics accommodates of a broad range of sample types to preserve activity and biological context, saving time from detrimental purification steps and clogging that takes other systems offline.

Interested in the Creoptix WAVEchips?

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Continue discovering the WAVEsystem

  • Measure interactions, not interference


    Engineered around a proprietary Grating-Coupled Interferometry (GCI) technology, the Creoptix® WAVE system builds on waveguide interferometry to achieve superior resolution in signal and time. With low limits of detection, the WAVEsystem generates accurate kinetic rates, affinity constants, and concentrations of label-free biomolecular interactions, even at low analyte abundance, with no loss of definition.

    WAV Edelta square web landscape
  • Fast, intuitive, automated


    Move seamlessly from sample to data in a simple stepwise process, generating outputs at the touch of a button. Benefit from waveRAPID, a novel method implemented on the existing WAVEdelta instruments allowing you to obtain kinetics of an interaction by injections from a single well.

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  • Smooth operations


    Our WAVEcare programs offer carefree or basic support for high-quality kinetic data and unparalleled performance. Ensure the continuous, high performance operation of your WAVEsystem by choosing the program that fits your needs.

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  • Together stronger


    Our worldwide community of customers and partners. Follow us as we continue to work together on research projects to create first-of-a-kind kinetic data and help make breakthrough discoveries.

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