Gathering Evidence Through Biochemical and Biophysical Characterization of Biologics
Why this webinar?
Antibodies are the most rapidly growing form of therapeutic, with proper methods of biochemical and biophysical characterization being essential as companies and researchers move to develop new candidates. In this webinar, Dr. Shawn Owen (University of Utah) discusses advanced characterization techniques to assess antibody-drug conjugates (ADCs), while Dr. Ellen Lee (Creoptix), goes deep into the biophysical characterization of biologics using the Grating-Coupled Interferometry (GCI) technology for label-free, real-time affinity and kinetics characterization. These methods can be used for the in-depth analysis of these biologics and for routine product validation.
What can I expect to learn during this webinar?
- Measuring kinetics in biofluids does provide valuable insights into a drug’s efficacy.
- How can I best characterize antibody drug conjugates using biochemical and biophysical techniques?
- Determination of level of payload and site of conjugation of ADCs using LC/MS.
- Thermal stability and binding affinity of ADCs characterization using DSC, IR, ITC and GCI.
- What is the Grating-Coupled Interferometry technology?
Field Application Scientist at Creoptix AG
Ellen Lee, PhD
With over 10 years of experience in protein research, Dr. Ellen Lee has a deep and solid understanding of molecular biology. Ellen has a PhD from the UT Southwestern Medical Center in Dallas and she has gathered extensive experience as a Field Application Scientist in the protein quality field, before joining Creoptix in 2019.
Assistant Professor at the Pharmaceutical Chemistry Department University of Utah
Shawn C. Owen, PhD
Dr. Owen is an Assistant Professor in the Pharmaceutical Chemistry department at the University of Utah. He is also an Adjunct Assistant Professor in the Internal Medicine, Biomedical Engineering, and Medicinal Chemistry Departments. His lab utilizes protein engineering and bioconjugation techniques in developing therapeutic and diagnostic platforms to enable precision medicine.